Coronary disease & ACSCase-control study
Plasma levels of polyols erythritol, mannitol, and sorbitol and incident coronary heart disease among women
- Nested case-control study
- prospective
Authors' conclusion
Higher levels of plasma erythritol and mannitol/sorbitol were related to elevated risks of CHD even after adjustment for diet, lifestyles, adiposity, and other risk factors. The unfavourable association of mannitol/sorbitol, but not of erythritol, with CHD risk remained significant independent of diabetes/hyperglycaemia.
Study context
- Population
- Women in the Nurses' Health Study; polyols measured at baseline (1989–90 or 2000–02)
- Participants
- 762 vs 762
- Comparison
- Plasma polyol levels: higher vs lower
- Casesn = 762
- Controlsn = 762reference
- Outcome
- Incident CHD
Main finding
As reported in the abstract
CHD risk by plasma polyol level
Relative risk (95% CI)P value
Erythritol per 1-SD incrementadjusted for diet quality, lifestyles, adiposity
1.15(1.04–1.28)
Mannitol/sorbitol per 1-SD incrementadjusted for diet quality, lifestyles, adiposity
1.16(1.05–1.28)
Erythritol Q4 vs Lowest quartile
1.55(1.13–2.14)
Erythritol Q4 vs Lowest quartilefurther adjusted for hypertension and dyslipidaemia
1.61(1.15–2.24)
P = 0.006Erythritol Q4 vs Lowest quartileafter adjustment for diabetes
1.21(0.86–1.70)
Mannitol/sorbitol Q4 vs Lowest quartilemultivariable-adjusted incl. diabetes
1.42(1.05–1.91)
P = 0.022Observational data: associations, not effects.
Further findings
Erythritol and cardiometabolic risk factors (Women's Lifestyle Validation Study, n = 728)
- Higher erythritol levels related to more adverse cardiometabolic risk factor status
Original publication
Plasma levels of polyols erythritol, mannitol, and sorbitol and incident coronary heart disease among women. Eur J Prev Cardiol. Published 4 September 2024. doi:10.1093/eurjpc/zwae288
Summarised from the published abstract; every number is checked against it