Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension
Authors' conclusion
Metabolic profiles in PAH are strongly related to survival and should be considered part of the deep phenotypic characterization of this disease.
Study context
- Population
- Well-phenotyped patients with idiopathic or heritable pulmonary arterial hypertension
- Participants
- 365 / 121 / 139
- Comparison
- Idiopathic or heritable pulmonary arterial hypertension (PAH) vs healthy controls and disease controls
- PAHn = 365
- Healthy controlsn = 121reference
- Disease controlsn = 139
- Outcome
- Plasma metabolites (UPLC mass spectrometry)
Main finding
As reported in the abstract
Metabolites distinguishing PAH from healthy controls, after correction for multiple testing (P<7.3e-5) and confounders
53
Of these, metabolites also discriminating PAH from disease controls
20
Metabolites prognostic in PAH
62
Prognostic metabolites independent of established prognostic markers
36
Observational data: associations, not effects.
Further findings
Calcium channel blocker responders
- Metabolic profiles similar to those of healthy controls
Original publication
Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension. Circulation. Published 21 November 2016. doi:10.
Summarised from the published abstract; every number is checked against it