Cardio-oncology & otherCohort study
Plasma Proteins Associated With the Immune Response to Anthracycline Cardiotoxicity in Patients With Hematologic Malignancies
- prospectively enrolled cohort
- aptamer-based proteomics platform
- validation in a second patient cohort
- mouse model of delayed doxorubicin cardiotoxicity
Authors' conclusion
Preanthracycline levels of the plasma immunologic proteins CPVL and PIGR were associated with a subsequent decline in cardiac function, representing potentially new inflammatory biomarkers of anthracycline cardiotoxicity.
Study context
- Population
- Patients with hematologic malignancies treated with anthracycline chemotherapydiscovery cohort 34 · validation cohort 32
- Participants
- 34 vs 32
- Exposure
- The correlation between protein levels and change in left ventricular ejection fraction
- discovery cohortn = 34
- validation cohortn = 32
Main finding
As reported in the abstract
Correlation of baseline plasma PIGR and CPVL with subsequent decline in left ventricular ejection fraction · baseline (before anthracycline chemotherapy)
PIGR: R
−0.74
PIGR: P
=0.0022
CPVL: R
−0.74
CPVL: P
=0.0022
Observational data: associations, not effects.
Further findings
Confirmation in human plasma and mice
- Findings were confirmed in human plasma samples using ELISA or Western blot, and similar changes in proteins were observed in mice treated with doxorubicin
Circulating IgA + B cells in mice
- doxorubicin treatment was associated with increased circulating levels of IgA + (immunoglobulin A) B cells in mice, which similarly correlated with the decline in left ventricular ejection fraction
Overall survival and progression-free survival
- The highest quartile of PIGR and CPVL levels was associated with decreased overall survival but not progression-free survival
Original publication
Plasma Proteins Associated With the Immune Response to Anthracycline Cardiotoxicity in Patients With Hematologic Malignancies. Circ Heart Fail. Published 27 August 2026. doi:10.1161/circheartfailure.125.013683
Summarised from the published abstract; every number is checked against it