Heart failure & cardiomyopathiesCohort study
Plasma Soluble Fms-Like Tyrosine Kinase-1, Placental Growth Factor, and Vascular Endothelial Growth Factor System Gene Variants as Predictors of Survival in Heart Failure
- Prospective cohort study
- matched healthy control cohort
Authors' conclusion
Plasma sFlt-1 concentrations have potential as an independent predictor of survival and may be complementary to established prognostic biomarkers in HF.
Study context
- Population
- Patients after an episode of acute decompensated heart failure (HF)Cox model n = 695, 246 deaths
- Participants
- 890 vs 201
- Exposure
- Plasma sFlt-1, placental growth factor (PlGF) and vascular endothelial growth factor (VEGF) system gene single nucleotide polymorphisms (SNPs) as prognostic biomarkers in HF
- PEOPLEn = 890
- Canterbury Healthy Volunteers Study (CHVS)n = 201reference
- Outcome
- All-cause death
Main finding
As reported in the abstract
All-cause death (Cox proportional hazards, PEOPLE)
Plasma sFlt-1 predicted survival, HR (95% CI 2.57-16.1; p < 0.001), independent of age, NT-proBNP, ischaemic aetiology, diabetic status and beta-blocker therapy
6.44
Observational data: associations, not effects.
Further findings
Mean plasma sFlt-1 · baseline · both sFlt-1 and PlGF
P < 0.044
Mean plasma PlGF · baseline · both sFlt-1 and PlGF
P < 0.044
sFlt-1, HFrEF vs HFpEF
- sFlt-1 higher in HFrEF than HFpEF
- P = 0.005
PGF gene SNPs
- rs2268616 univariately associated with death
- P = 0.016
- rs2268616 and rs2268614 genotypes associated with PlGF levels
Original publication
Plasma Soluble Fms-Like Tyrosine Kinase-1, Placental Growth Factor, and Vascular Endothelial Growth Factor System Gene Variants as Predictors of Survival in Heart Failure. Eur J Heart Fail. Published 9 July 2024. doi:10.1002/ejhf.3368
Summarised from the published abstract; every number is checked against it