Arrhythmias & electrophysiology
A comparison of simplified or conventional antithrombotic regimens after left atrial appendage closure in patients at high bleeding risk: the PLATEBRISK study
Authors' conclusion
In patients with very high bleeding risk, a simplified ATT after LAAO seems to be as effective as conventional protocols. Furthermore, patients with a history of major bleeding experienced a lower risk of major bleeding with the simplified ATT.
Study context
- Population
- Very high bleeding risk patients (Bleeding Academic Research Consortium (BARC) definition: >4% risk of BARC 3 to 5 bleeding or >1% risk of intracranial bleeding) who underwent LAAO; mean CHA2DS2-VASc 4.5±1.5, HAS-BLED 3.7±1.0
- Participants
- 1,135 participants
- Exposure
- Simplified vs conventional antithrombotic treatment after LAAO
- Outcome
- Composite of:
- Death
- Stroke
- TIA
- Device-related thrombus
- Major bleeding
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
No differences in the composite endpoint between the 2 groups
HR 0.81, 95% CI: 0.59-1.11
p=0.188
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Major bleeding, prior major bleeding (subgroup) | 0.61 (0.36–0.99) | P = 0.049 | |
| 0.20.5125Hazard ratio (log scale) |
Safety
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Major bleeding · first yearNumerically lower, not statistically significant | 0.67 (0.41–1.10) | P = 0.104 | |
| 0.512Hazard ratio (log scale) |
Original publication
A comparison of simplified or conventional antithrombotic regimens after left atrial appendage closure in patients at high bleeding risk: the PLATEBRISK study. EuroIntervention. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →