Polygenic risk score for coronary artery disease across the spectrum of atherosclerotic disease
Authors' conclusion
A CAD PRS was associated with incident major coronary events in all ASCVD categories. Although genetics provided the strongest relative association in patients without established ASCVD, the absolute risk gradient was comparable for patients with and without ASCVD.
Study context
- Population
- Genotyped trial participants with atherosclerotic cardiovascular disease (ASCVD) and a prior ischemic event, ASCVD without event, or without overt ASCVD47,456 (79%) established ASCVD
- Participants
- 59,905 participants
- Comparison
- High and intermediate vs low coronary artery disease (CAD) polygenic genetic risk, across ASCVD categories
- Outcome
- Major coronary event:
- Coronary death
- MI
- Coronary revascularization
Methodological detailsgenome-wide CAD polygenic risk scores (PRS)
- Genome-wide CAD PRS
Main finding
As reported in the abstract
Each group vs lowHazard ratio (95% CI)P value
High
2.06(1.88–2.24)
P < 0.001Intermediate
1.57(1.45–1.70)
P < 0.001Further findings
| Outcome | HR |
|---|---|
| Major coronary events by ASCVD category (subgroup)High vs Low · without overt ASCVD | 4.63 |
| Major coronary events by ASCVD category (subgroup)High vs Low · ASCVD without ischemic event | 1.73 |
| Major coronary events by ASCVD category (subgroup)High vs Low · ASCVD with ischemic event | 1.63 |
- Major coronary events by ASCVD category (subgroup): Pinteraction<0.001
Absolute risk difference, high vs low genetic risk, across ASCVD categories · 3 years
- Comparable across ASCVD categories
- 5.0-7.0%
Original publication
Polygenic risk score for coronary artery disease across the spectrum of atherosclerotic disease. Eur J Prev Cardiol. Published 28 October 2025. doi:10.
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