Polygenic risk scores associate with blood pressure traits across the lifespan
Authors' conclusion
Genetic risk factors are associated with BP traits across the lifespan, beginning in the first years of life.
Study context
- Population
- Independent cohorts of children and adults; Polygenic risk scores (PRSs) for systolic BP (SBP), diastolic BP (DBP) and pulse pressure87 PRSs developed
- Exposure
- High and low vs average blood pressure (BP) PRS
- Outcome
- BP trajectories by PRS decile
- Follow-up
- Across the lifespan
Methodological detailspolygenic risk score development and validation, independent cohorts of children and adults, PRSs built with genome-wide significant weights, pruning and thresholding, or Bayesian regression; top performer per trait applied
- Polygenic risk score development and validation
- Independent cohorts of children and adults
- PRSs built with genome-wide significant weights, pruning and thresholding, or Bayesian regression; top performer per trait applied
Main finding
As reported in the abstract
- Differences between low, average and high PRS emerge in the first years of life and are maintained throughout adulthood
Observational data: associations, not effects.
Further findings
Cardiovascular and renal disease risk
- Increased risk in top decile and reduced risk in bottom decile vs rest of population
Original publication
Polygenic risk scores associate with blood pressure traits across the lifespan. Eur J Prev Cardiol. Published 26 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it