Acute cardiac care & resuscitationCase-control study
Population-Based Analysis of Rare Genetic Variants in Sudden Cardiac Arrest
- Gene-collapsing case-control analysis
- population-based
- whole genome sequencing
- 2 community-based studies in Oregon and California
Authors' conclusion
Specific disease-causing variants identified in 15 arrhythmia and cardiomyopathy genes were associated with an increased risk of SCA in the community. These findings will enable targeted SCA prevention strategies in family members harboring variants in these SCA-associated genes.
Study context
- Population
- Survivors and nonsurvivors of sudden cardiac arrest (SCA) in the general population, compared with control participants from the ARIC (Atherosclerosis Risk in Communities) studyPatients with SCA 3,264 · Control participants (ARIC) 13,258
- Participants
- 3,264 vs 13,258
- Comparison
- Patients with SCA compared with control participants from the ARIC study
- SCA groupn = 3,264
- ARICn = 13,258reference
Main finding
As reported in the abstract
Disease-causing (likely pathogenic or pathogenic) variants in 63 candidate genes associated with arrhythmia/cardiomyopathy
Odds ratio
1.59
P < 0.001
Events by group
Observational data: associations, not effects.
Further findings
| Outcome | Values | OR | P value |
|---|---|---|---|
| Disease-causing variant in the subgroup of patients with a nonischemic SCA (subgroup) | Nonischemic SCA subgroup 6.1% | 2.52 | P < 0.001 |
Genes associated with an increased risk of SCA
- Genes identified
- 15
- ACTC1, BAG3, CACNA1C, DES, DSG2, DSP, FLNC, KCNH2, KCNQ1, LMNA, MYBPC3, MYH7, PKP2, RBM20, and TTN
Original publication
Population-Based Analysis of Rare Genetic Variants in Sudden Cardiac Arrest. JACC Clin Electrophysiol. Published 20 May 2026. doi:10.1016/j.jacep.2026.03.016
Summarised from the published abstract; every number is checked against it