Prevention & lipidsCohort study
Portfolio Diet Score and Risk of Cardiovascular Disease: Findings From 3 Prospective Cohort Studies
- Prospective cohort study
- 3 prospective cohorts
- multivariable-adjusted
Authors' conclusion
The PDS was associated with a lower risk of CVD, including CHD and stroke, and a more favorable blood lipid and inflammatory profile, in 3 large prospective cohorts.
Study context
- Population
- Women (NHS, NHS II) and men (HPFS) without cardiovascular disease (CVD) or cancer at baseline3 cohorts: 73,924 + 92,346 + 43,970
- Exposure
- Highest vs lowest quintile of Portfolio Diet Score
- Outcome
- Total CVD, CHD and stroke
- Follow-up
- Up to 30 years
Main finding
As reported in the abstract
Highest PDS quintile vs Lowest PDS quintilePooled hazard ratio (95% CI)P value
total CVD
0.86(0.81–0.92)
P < 0.001for trendCHD
0.86(0.80–0.93)
P = 0.0001for trendstroke
0.86(0.78–0.95)
P = 0.0003for trend- Incident CVD cases
- 16 917
- Coronary heart disease (CHD) cases
- 10 666
- Strokes
- 6473
Observational data: associations, not effects.
Further findings
| Outcome | pooled HR (95% CI) | |
|---|---|---|
| Per 25-percentile higher PDS — 25-percentile higher PDS · total CVD | 0.92 (0.89–0.95) | |
| Per 25-percentile higher PDS — 25-percentile higher PDS · CHD | 0.92 (0.88–0.95) | |
| Per 25-percentile higher PDS — 25-percentile higher PDS · stroke | 0.92 (0.87–0.96) | |
| 0.512Pooled hazard ratio (log scale) |
Sensitivity and subgroup analyses; linearity
- Consistent across sensitivity and most subgroup analyses; no departure from linearity for CVD, CHD or stroke
Blood lipid and inflammatory profile (subset)
- Higher Portfolio Diet Score (PDS) associated with more favorable lipid and inflammatory profile
Original publication
Portfolio Diet Score and Risk of Cardiovascular Disease: Findings From 3 Prospective Cohort Studies. Circulation. Published 25 October 2023. doi:10.1161/circulationaha.123.065551
Summarised from the published abstract; every number is checked against it