Heart failure & cardiomyopathiesCohort study
Post-capillary pulmonary hypertension in heart failure: impact of current definition in the PH-HF multicentre study
- Prospective cohort study
- multicentre
Authors' conclusion
This study is the first emphasizing the impact of the new pcPH definition on CpcPH prevalence and validating the prognostic value of mPAP > 20 mmHg and PVR > 2 WU among HF patients.
Study context
- Population
- Stable left heart failure (HF) patients needing right heart catheterization, enrolled 2010–2018
- Participants
- 662 patients
- Exposure
- Post-capillary pulmonary hypertension (pcPH) definitions and prognostic value of mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR)
- Outcome
- All-cause death or hospitalization for HF
Main finding
As reported in the abstract
All-cause death or HF hospitalisation (multivariable Cox)
Hazard ratio (95% CI)P value
mPAP
1.02(1.00–1.03)
P = 0.01PVR
1.07(1.00–1.14)
P = 0.03- 2022 definition: worse survival with pcPH vs no pcPH (log-rank)
- P = 0.02
- 2022 definition: worse survival with CpcPH vs IpcPH (log-rank)
- P = 0.003
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Survival by 2022 definition — pcPH vs No pcPH · worse survival with pcPH | P = 0.02 |
| Survival by 2022 definition — CpcPH vs IpcPH · worse survival with CpcPH | P = 0.003 |
pcPH and CpcPH prevalence with lowered thresholds
- Lowering mPAP from 25 to 20 mmHg: increase in pcPH prevalence
- +10%
- Lowering PVR from 3 to 2: increase in CpcPH prevalence (significant net reclassification improvement for primary outcome)
- +60%
Original publication
Post-capillary pulmonary hypertension in heart failure: impact of current definition in the PH-HF multicentre study. Eur Heart J. Published 26 July 2024. doi:10.1093/eurheartj/ehae467
Summarised from the published abstract; every number is checked against it