Post-PCI Global QFR and Long-Term Outcomes in ACS: Findings From the FAVOR III China Trial

Shen, X; Zhang, H; Li, Z; Guan, C; Jin, C; Jin, Z; Yu, B; Zhou, Y; Wang, J; Chen, Y; Pu, J; Chen, L; Qu, X; Yang, J; Liu, X; Zhang, Q; Ye, F; Wu, Y; Qiao, S; Stone, GW; Fu, G; Song, L; Qiu, F

doi:10.1016/j.jcin.2026.01.279

Coronary disease & ACS

Post-PCI Global QFR and Long-Term Outcomes in Acute Coronary Syndrome (ACS): Findings From the FAVOR III China Trial

JACC Cardiovasc IntervPublished 13 Apr 2026Secondary analysis of the FAVOR III China randomised trial

Primary result · 3-year MACEResultAdjusted hazard ratio 1.53 95% CI 1.10–2.13

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Authors' conclusion

Residual global μQFR is a robust angiographic index for post-PCI ischemia burden and long-term risk stratification. In patients with ACS, QFR-guided PCI achieving low residual global ischemia was associated with the most favorable 3-year prognosis.

Study context

Population: ACS patients (STEMI, NSTEMI, unstable angina) undergoing percutaneous coronary intervention (PCI) in the FAVOR III China trial2,241 (92.3%) analyzable μQFR
Participants: 2,428 patients

Comparison: Low vs high residual global μQFR after PCI
High-riskn = 407
Primary endpoint: MACE:
All-cause death
MI
Ischemia-driven revascularization
Follow-up: 3 years

Methodological detailspost hoc analysis

Post hoc analysis

Primary result

3-year MACE

Adjusted hazard ratio

1.53

95% CI 1.10–2.13

P = 0.01

By group

High-risk21.2%

Low-risk10.4%

High-risk vs Low-risk

adjusted HR 1.53 (95% CI 1.10–2.13); P = 0.01

As reported in the abstract

Further findings

Outcome	High-risk	Low-risk	← Lower risk ←→ Higher risk →	Estimate	P value
MACE excluding periprocedural MI · 3 years	16.2%	7.8%	0.20.5125	adjusted HR 1.72 (95% CI 1.17–2.53)	P = 0.006
MACE in low residual ischemia, QFR-guided vs angiography-guided PCI (subgroup)			0.20.5125	HR 0.73 (95% CI 0.55–0.97)
			0.20.5125Ratio (log scale)

Major adverse cardiac events (MACE) in low residual ischemia, QFR-guided vs angiography-guided PCI (subgroup): QFR-guided PCI 8.8%
MACE in low residual ischemia, QFR-guided vs angiography-guided PCI (subgroup): Angiography-guided PCI 11.9%

Prognostic effect of residual global μQFR, by QFR- vs angiography-guided PCI (subgroup)

Consistent across QFR- and angiography-guided subgroups

P for interaction = 0.35

Original publication

Post-PCI Global QFR and Long-Term Outcomes in ACS: Findings From the FAVOR III China Trial. JACC Cardiovasc Interv. Published 13 April 2026. doi:10.1016/j.jcin.2026.01.279

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Summarised from the published abstract; every number is checked against it