Heart failure & cardiomyopathiesRandomised controlled trial
Potassium Nitrate in Heart Failure With Preserved Ejection Fraction
- Randomised controlled trial
- multicentre
- double-blind
- crossover
Authors' conclusion
In this study, potassium nitrate did not improve aerobic capacity, total work, or quality of life in participants with HFpEF.
Study context
- Population
- Symptomatic (NYHA class II/III) heart failure with preserved ejection fraction (HFpEF) with objective signs of elevated LV filling pressurescrossover, 1-week washout
- Participants
- 84 participants
- Comparison
- Potassium nitrate vs potassium chloride
- KNO3n = 77
- KCln = 74reference
- Primary endpoint
- Coprimary: peak oxygen uptake and total work performed during maximal effort incremental cardiopulmonary exercise test
Primary result
As reported in the abstract
| Group | Peak oxygen uptake | Total work |
|---|---|---|
| KNO3 | 10.23 [SD, 0.43] mL/min/kg | 25.9 [SD, 3.65] kilojoules |
| KCl | 10.17 [SD, 0.43] mL/min/kg | 23.63 [SD, 3.63] kilojoules |
- KNO3 vs KCl: P = 0.73 — peak oxygen uptake
- KNO3 vs KCl: P = 0.29 — total work
Secondary outcomes
Trough serum nitric oxide metabolites · 6 weeks
P < 0.001
Vasodilatory reserve and quality of life (KCCQ)
- KNO3 did not improve vasodilatory reserve or quality of life
Original publication
Potassium Nitrate in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. Published 1 March 2025. doi:10.1001/jamacardio.2024.4417
Summarised from the published abstract; every number is checked against it