Heart failure & cardiomyopathiesCohort study
Pre-Diagnostic Free Androgen and Estradiol Levels Influence Heart Failure Risk in Both Women and Men: A Prospective Cohort Study in the UK Biobank
- Prospective cohort study
Authors' conclusion
Sex hormones potentially influence HF pathogenesis and may offer pathways for interventions.
Study context
- Population
- UK Biobank participants free of prevalent CVD and heart failure (HF) at baselinemen and women with complete data
- Exposure
- Quartiles of free androgen, testosterone and estradiol indices, Q4 vs Q1
- Outcome
- Incident HF
Main finding
As reported in the abstract
Incident HF by sex hormone index quartile
Q4 vs Q1Hazard ratio (95% CI)P value
FAI, men
0.86(0.79–0.94)
p-trendcontinuous < 0.0001FAI, post-menopausal women
0.83(0.73–0.95)
FTI, men
0.91(0.83–0.98)
FEI, men
0.76(0.59–0.98)
FEI, pre-menopausal women
2.16(1.11–4.18)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pre-Diagnostic Free Androgen and Estradiol Levels Influence Heart Failure Risk in Both Women and Men: A Prospective Cohort Study in the UK Biobank. Eur J Heart Fail. Published 25 March 2024. doi:10.1002/ejhf.3189
Summarised from the published abstract; every number is checked against it