Congenital heart diseaseCohort study
Pre-existing maternal cardiovascular disease and the risk of offspring cardiovascular disease from infancy to early adulthood
- Nationwide cohort study
- register-based
- negative control (paternal cardiovascular disease (CVD))
Authors' conclusion
Maternal CVD was associated with an increased risk of CVD in offspring during childhood and young adulthood.
Study context
- Population
- Live singletons without major malformations or congenital heart disease born 1992–2019 in Swedenoffspring analysed
- Participants
- 2,597,786 singletons
- Exposure
- Maternal pre-existing CVD vs no maternal CVD
- Maternal CVDn = 26,471
- Outcome
- Offspring CVD from infancy to early adulthood
- Follow-up
- Median 14 years (range 1-29 years)
Main finding
Offspring CVD
Adjusted hazard ratio
2.09
95% CI 1.83–2.39
Maternal CVD vs No maternal CVD
adjusted HR 2.09 (95% CI 1.83–2.39)
As reported in the abstract
- Offspring diagnosed with CVD (all)
- 17 382
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Offspring CVD by paternal CVD (negative control) · smaller magnitude than maternal CVD · negative control | 1.49 (1.32–1.68) | |
| Offspring CVD by maternal CVD type — maternal arrhythmia vs No maternal CVD | 2.94 (2.41–3.58) | |
| Offspring CVD by maternal CVD type — vascular vs No maternal CVD | 1.59 (1.21–2.10) | |
| Offspring CVD by maternal CVD type — structural heart diseases vs No maternal CVD | 1.48 (1.08–2.02) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Pre-existing maternal cardiovascular disease and the risk of offspring cardiovascular disease from infancy to early adulthood. Eur Heart J. Published 4 September 2024. doi:10.1093/eurheartj/ehae547
Summarised from the published abstract; every number is checked against it