Heart failure & cardiomyopathies
Pre-Operative Pulmonary Artery Pulsatility Index Does not Predict Mortality Post-Cardiac Transplantation
Authors' conclusion
The PAPi was not able to discriminate mortality outcomes for patients post-cardiac transplantation. Pulmonary vascular resistance remains a marker of mortality in an LVAD cohort bridged to transplant (central illustration).
Study context
- Population
- Patients who underwent cardiac transplantation over a 6 year period3 excluded (missing data)
- Participants
- 158 patients
- Exposure
- Pulmonary artery pulsatility index (PAPi) vs pulmonary vascular resistance (PVR) for predicting outcomes post-cardiac transplantation
- LVADn = 43
- Outcome
- Morbidity and all-cause mortality post-transplantation (prognostic significance of PAPi vs PVR)
Methodological detailsPre-operative right heart catheter data; PAPi = (sPAP − dPAP)/right atrial (RA) pressure
- Pre-operative right heart catheter data; PAPi = (sPAP − dPAP)/RA pressure
Main finding
As reported in the abstract
- Non-LVAD: no significant difference in PAPi or PVR, no association with post-operative outcome (incl. by natural history sub-type)
- all P > 0.05
- LVAD: PVR predictive of post-operative mortality (mortality 2.8 ± 1.3 WU vs alive 1.7 ± 0.7 WU)
- P = 0.005
Observational data: associations, not effects.
Original publication
Pre-Operative Pulmonary Artery Pulsatility Index Does not Predict Mortality Post-Cardiac Transplantation. ESC Heart Fail. Published 31 March 2023. doi:10.
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