Acute cardiac care & resuscitation
Prearrest vital sign abnormalities are associated with adverse outcomes in pediatric Intensive Care Unit (ICU) cardiac arrest: a get with the guidelines-resuscitation analysis
Authors' conclusion
Prearrest vital sign abnormalities are common in pediatric ICU IHCA and independently associated with worse outcomes
Study context
- Population
- Children with ≥1 min of cardiopulmonary resuscitation (CPR) in an ICU (IHCA), 2007 to 2022, with prearrest vital signs
- Participants
- 2,875 children
- Exposure
- Abnormal vs normal prearrest vital signs
- Abnormal vital signn = 1,790
- Outcome
- Survival to hospital discharge
Methodological detailsregistry (Get with The Guidelines-Resuscitation®), multivariable regression
- Registry (Get with The Guidelines-Resuscitation®)
- Multivariable regression
Main finding
As reported in the abstract
Adjusted odds ratio (95 % CI)P value
Low SBP (<5%)lowest odds of any vital sign
0.56(0.46–0.68)
P < 0.011 abnormal vital sign vs 0
0.62(0.51–0.76)
P < 0.012 abnormal vital signs vs 1
0.72(0.53–0.97)
P = 0.033 abnormal vital signs vs 2
0.53(0.33–0.86)
P < 0.01Observational data: associations, not effects.
Further findings
ROSC, low SBP (<5%)
| Comparison | aOR (95 % CI) | P value | |
|---|---|---|---|
| Low SBP (<5%) | 0.63 (0.54–0.73) | P < 0.01 | |
| 0.512Adjusted odds ratio (log scale) |
- Prevalence of ≥1 abnormal vital sign
- 62.3 % · 1790
Original publication
Prearrest vital sign abnormalities are associated with adverse outcomes in pediatric ICU cardiac arrest: a get with the guidelines-resuscitation analysis. Resuscitation. Published 24 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it