Heart failure & cardiomyopathiesCohort study
Precision prediction of heart failure events in patients with dilated cardiomyopathy and mildly reduced ejection fraction using multi‐parametric cardiovascular magnetic resonance
- Prospective observational cohort study
Authors' conclusion
Multi-parametric CMR has utility for precision prognostic stratification of patients with DCMmrEF. LV GLS stratifies risk of progressive HF, while LGE stratifies SCD risk.
Study context
- Population
- Patients with DCM and mildly reduced EF (LV ejection fraction (LVEF) ≥40% by cardiovascular magnetic resonance (CMR))
- Participants
- 355 patients
- Exposure
- Left ventricular (LV) global longitudinal strain (GLS) and late gadolinium enhancement (LGE) by CMR as predictors of heart failure (HF) events and sudden cardiac death (SCD)
- Outcome
- (i) HF hospitalization, LV assist device implantation or HF death; (ii) SCD or aborted SCD
- Follow-up
- Median 7.8 years
Main finding
As reported in the abstract
HF events and SCD/aSCD
Hazard ratio (95% CI)P value
LV GLS (per %)HF events, multivariable
1.10(1.00–1.21)
P = 0.045LV GLS > −15.4%HF events, multivariable
2.70(1.30–5.94)
P = 0.008LGE presenceHF events
1.49(0.73–3.01)
P = 0.270LV GLS (per %)SCD/aSCD
1.07(0.95–1.22)
P = 0.257LGE presenceSCD/aSCD
3.58(1.39–9.23)
P = 0.008Per %, as printed
- HF events
- 32 patients (9%)
- SCD or aborted SCD (aSCD)
- 19 (5%)
Observational data: associations, not effects.
Original publication
Precision prediction of heart failure events in patients with dilated cardiomyopathy and mildly reduced ejection fraction using multi‐parametric cardiovascular magnetic resonance. Eur J Heart Fail. Published 15 August 2024. doi:10.1002/ejhf.3425
Summarised from the published abstract; every number is checked against it