Prevention & lipidsCohort study
Prediabetes and 20-year cardiovascular disease incidence: the ATTICA cohort study (2002–2022)
- Prospective cohort study
- population-based
Authors' conclusion
Prediabetes defined by IFG is an independent predictor of CVD, beyond traditional cardiometabolic risk factors. Moreover, earlier T2D onset markedly increases CVD risk
Study context
- Population
- Adults free of cardiovascular disease (CVD) and T2D at baseline, rural population of the greater Athens area, Greece (ATTICA study)
- Participants
- 1,796 adults
- Exposure
- IFG vs normal fasting glucose (NFG)
- IFGn = 333
- NFGn = 1,463reference
- Outcome
- Incident fatal or non-fatal CVD events
- Follow-up
- 20-year (2002-2022)
Main finding
CVD incidence · 20 years
Hazard ratio
1.21
95% CI 1.01–1.48
P = 0.038
By group
IFG vs NFG
HR 1.21 (95% CI 1.01–1.48); P = 0.038
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | IFG | NFG | P value |
|---|---|---|---|
| Progression to T2D · 20 years | all participants | 13.5% | P < 0.001 |
CVD risk with earlier T2D onset (before 10 years), landmark analysis
- Adjusted OR for subsequent CVD
- 2.46
- p < 0.05
Original publication
Prediabetes and 20-year cardiovascular disease incidence: the ATTICA cohort study (2002–2022). Eur J Prev Cardiol. Published 23 March 2026. doi:10.1093/eurjpc/zwag164
Summarised from the published abstract; every number is checked against it