Heart failure & cardiomyopathiesCohort study
Prediabetes, Malignant Left Ventricular Hypertrophy, and Risk of Incident Heart Failure Among Hypertensive Adults
- prospective cohort analysis
Authors' conclusion
Among hypertensive adults, the coexistence of prediabetes and malignant LVH identifies a subgroup at substantially elevated HF risk. Integrating glycemic status, ECG findings, and cardiac biomarkers may enhance HF risk stratification and inform preventive strategies.
Study context
- Population
- Hypertensive adults without diabetes or prior heart failure (HF) from the SPRINT (Systolic Blood Pressure Intervention Trial)hypertensive adults without diabetes or prior HF
- Participants
- 8,131 adults
- Exposure
- Prediabetes combined with malignant left ventricular hypertrophy (LVH) vs normoglycemic adults without malignant LVH
Main finding
As reported in the abstract
HF events · median 3.3-year follow-up
HF events
115
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| HF risk — Prediabetes and malignant LVH vs Normoglycemic adults without malignant LVH | adjusted HR 3.55 (95% CI 1.98–6.36) | |
| HF risk — Prediabetes with LVH plus myocardial injury vs Normoglycemic adults without malignant LVH | HR 4.02 (95% CI 2.21–7.30) | |
| HF risk — Prediabetes with LVH plus myocardial stress vs Normoglycemic adults without malignant LVH | HR 4.04 (95% CI 2.22–7.34) | |
| HF risk — Prediabetes alone vs Normoglycemic adults without malignant LVH · not associated with HF | adjusted HR 1.24 (95% CI 0.80–1.91) | |
| 0.10.31310Ratio (log scale) |
Original publication
Prediabetes, Malignant Left Ventricular Hypertrophy, and Risk of Incident Heart Failure Among Hypertensive Adults. JACC Adv. Published 5 August 2026. doi:10.1016/j.jacadv.2026.103096
Summarised from the published abstract; every number is checked against it