Arrhythmias & electrophysiology
Predicting arrhythmic event score in Brugada syndrome: Worldwide pooled analysis with internal and external validation
An erratum to this article was published (Heart Rhythm, Sep 2024 ↗)
Authors' conclusion
The PAT score was shown to be useful in predicting MAE for primary prevention in patients with Brugada syndrome.
Study context
- Population
- Patients with Brugada syndrome
- Participants
- 7,358 patients67 studies
- Comparison
- PAT score vs BRUGADA-RISK score, Shanghai Score System and Sieira et al score
- Outcome
- Discrimination for major arrhythmic events (ROC analysis) in external validation cohort
Methodological detailsinternal validation, external validation, Internal validation: 105 Asian patients (follow-up 8.0 ± 4.1 years), External validation: 164 multiracial patients (mean follow-up 8.0 ± 6.9 years)
- Internal validation
- External validation
- Internal validation: 105 Asian patients (follow-up 8.0 ± 4.1 years)
- External validation: 164 multiracial patients (mean follow-up 8.0 ± 6.9 years)
Pooled result
As reported in the abstract
Discrimination for MAE (ROC), external validation cohort
| Group | ROC |
|---|---|
| PAT score | 0.9671 |
| BRUGADA-RISK score | 0.7210 |
| Shanghai Score System | 0.7079 |
| Sieira et al score | 0.8174 |
ROC
PAT score0.9671
BRUGADA-RISK score0.7210
Shanghai Score System0.7079
Sieira et al score0.8174
- PAT score vs BRUGADA-RISK score: P = 0.006
- PAT score vs Shanghai Score System: P = 0.003
- PAT score vs Sieira et al score: P = 0.026
Further pooled results
- First major arrhythmic events (MAE), PAT score ≥ 10
- 95.5% · sensitivity · specificity 89.1% · ROC 0.9460
- Recurrent MAE, PAT score ≥ 10
- 15.4% · sensitivity · specificity 93.3% · ROC 0.7061
Pooled risk factors for MAE
- Risk factors significant on pooled odds ratios (ORs)
- 15 of 23
Original publication
Predicting arrhythmic event score in Brugada syndrome: Worldwide pooled analysis with internal and external validation. Heart Rhythm. Published 23 June 2023. doi:10.
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