Meta-analysis
Predicting worsening heart failure hospitalizations in patients with implantable cardioverter defibrillators: is it all about alerts? A pooled analysis of nine trials
- Pooled analysis of nine clinical trials
Authors' conclusion
The HF score was significantly higher at, and further increased during 12 weeks before WHFH, as compared to the no WHFH group, with seven components showing different behaviour and contribution.
Study context
- Population
- Patients with a defibrillator capable of atrial sensing and remote monitoring, EF ≤ 35%, NYHA class II/III, no long-standing AF
- Participants
- 2,050 patients · 9 trials
- Comparison
- WHFH vs no WHFH
- Outcome
- Temporal trends of the HeartInsight HF score and its seven components before WHFH vs 12-week trends without WHFH
- Follow-up
- 12 weeks before WHFH
Pooled result
Mean HF score
Difference
+22%
P = 0.003
By group
WHFH
42.3
mean · SD 26.1
No WHFH
30.7
mean · SD 20.6
As reported in the abstract
Further pooled results
Algorithm components vs no WHFH
- Already higher 12 weeks before WHFH: 24 h HR, HR variability, thoracic impedance
- Significantly increased until WHFH: nocturnal HR, atrial tachyarrhythmia, ventricular extrasystoles, patient activity
Original publication
Predicting worsening heart failure hospitalizations in patients with implantable cardioverter defibrillators: is it all about alerts? A pooled analysis of nine trials. Europace. Published 31 January 2024. doi:10.1093/europace/euae032
Summarised from the published abstract; every number is checked against it