Heart failure & cardiomyopathiesCohort study
Prediction of clinical outcomes based on phenotypic grouping using left ventricular and left atrial strains in patients with heart failure with preserved ejection fraction (HFpEF)
- multicentre STRATS-AHF registry
Authors' conclusion
Combined LV and LA strain assessment identified distinct HFpEF phenotypes and provided valuable prognostic information in HFpEF patients.
Study context
- Population
- HFpEF patients in the multicentre STRATS-AHF registryHFpEF patients (mean age: 73.4 years, 60.4% female) · Group 1 340 · Group 2 239 · Group 3 186 · Group 4 419
- Participants
- 1,184 patients
- Exposure
- Phenotyping based on dual-chamber strain analysis (LVGLS ≤−16%; LARS ≥18%), Groups 2–4 compared with Group 1
- Group 1n = 340reference
- Group 2n = 239
- Group 3n = 186
- Group 4n = 419
- Outcome
- All-cause mortality
- Follow-up
- 5-year
Main finding
As reported in the abstract
- Group 2 · univariate
- HR 1.341; P = 0.016
- Group 3 · univariate
- HR 1.578; P < 0.001
- Group 4 · univariate
- HR 1.822; P < 0.001
- Group 2 · multivariate
- adjusted HR 1.664; P = 0.011
- Group 4 · multivariate
- adjusted HR 1.660; P = 0.026
- Group 3 · adjusting for other variables, including age and atrial fibrillation (AF); insignificant
- adjusted HR 1.509; P = 0.171
Observational data: associations, not effects.
Further findings
| Outcome | Group 1 | Group 2 | Group 3 | Group 4 |
|---|---|---|---|---|
| Baseline characteristics: AF prevalence, E/e′ ratio, right ventricular global longitudinal strain | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract | prevalence of atrial fibrillation 62.8% |
Baseline characteristics: AF prevalence, E/e′ ratio, right ventricular global longitudinal strain
- Group 4 exhibited the highest E/e′ ratio and the most impaired right ventricular global longitudinal strain
Original publication
Prediction of clinical outcomes based on phenotypic grouping using left ventricular and left atrial strains in patients with HFpEF. Eur Heart J Cardiovasc Imaging. Published 7 July 2026. doi:10.1093/ehjci/jeag173
Summarised from the published abstract; every number is checked against it