Valvular & structural heart disease
Prediction of the Individual Aortic Stenosis Progression Rate and its Association With Clinical Outcomes
Authors' conclusion
AVA decreases linearly in individual patients, and faster progression is independently associated with higher mortality.
Study context
- Population
- Patients with moderate AS presenting December 2011–December 2022 with echocardiograms available
- Participants
- 540 patients2,937 echocardiograms
- Outcome
- Predictors of AS progression rate (AVA decline) and its association with clinical outcomes
Methodological detailslongitudinal, single-centre
- Longitudinal
- Single-centre
Main finding
As reported in the abstract
AS progression rate
Median aortic valve area (AVA) decrease (linear progression)
0.09 cm²/y
Median peak jet velocity increase
0.17 m/s/y
Observational data: associations, not effects.
Further findings
Rapid progression and clinical outcomes
| HR (95% CI) | ||
|---|---|---|
| Rapid progressionAll-cause mortality · independently associated | 1.77 (1.26–2.48) | |
| Rapid progressionAortic valve replacement · independently associated | 3.44 (2.55–4.64) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Prediction of the Individual Aortic Stenosis Progression Rate and its Association With Clinical Outcomes. JACC Adv. Published 6 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →