Arrhythmias & electrophysiologyMeta-analysis
Prediction of ventricular arrhythmias and sudden cardiac death by quantification and location of late gadolinium enhancement on cardiac magnetic resonance: a systematic review and meta-analysis
- Systematic review and meta-analysis of observational studies
- random-effects models
Searched PubMed, Embase and Web of Science on 20 November 2024
Authors' conclusion
Quantitative LGE assessment provides little incremental prognostic utility over dichotomous LGE detection.
Study context
- Population
- Non-ischaemic cardiomyopathy (NICM) with CMR late gadolinium enhancement (LGE) assessment41 studies
- Comparison
- LGE presence and quantified LGE burden for prediction of ventricular arrhythmia (VA)/sudden cardiac death (SCD)
- Outcome
- VA/SCD
Pooled result
As reported in the abstract
Presence of any LGE: pooled HR
3.31 (95% CI 2.58-4.24)
Each additional 1% (or 1 g) of LGE: relative risk increase (range 10-20%), independent of LVEF
12%
Original publication
Prediction of ventricular arrhythmias and sudden cardiac death by quantification and location of late gadolinium enhancement on cardiac magnetic resonance: a systematic review and meta-analysis. Europace. Published 7 November 2025. doi:10.1093/europace/euaf214
Summarised from the published abstract; every number is checked against it