Heart failure & cardiomyopathies
Prediction and Prognostic Role of Left Ventricular Systolic Dysfunction in Family Screening for Dilated Cardiomyopathy and Non-Dilated Left Ventricular Cardiomyopathy
Authors' conclusion
Relatives of DCM/NDLVC probands who developed LV systolic dysfunction during a long follow-up had a significant increased risk of major adverse cardiovascular outcomes. However, LV systolic dysfunction detected by FSP showed a better prognosis. In this context, genetics, Holter ECG and LV-GLS demonstrated their functional role for disease and event prediction.
Study context
- Population
- First-degree relatives of probands with DCM or non-dilated left ventricular (NDLVC)
- Participants
- 492 first-degree relatives
- Exposure
- Relatives with vs without left ventricular (LV) systolic dysfunction; LV systolic dysfunction detected by FSP vs not
- Outcome
- All-cause death and heart transplantation
- Follow-up
- Median 110 months (IQR 57-188 months)
Main finding
As reported in the abstract
P < 0.001
- Primary outcomes only in subjects who developed LV systolic dysfunction (19 vs. 0)
- P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Secondary arrhythmic outcomes
P < 0.001
Secondary heart failure (HF) and arrhythmic outcomes, LV systolic dysfunction vs none
- HF: 12 vs. 0
- P = 0.005
- Arrhythmic: 30 vs. 0
- P < 0.001
Risk factors and predictors of LV systolic dysfunction
- Family history of arrhythmia and P/LP variant carriage main risk factors; LV global longitudinal strain (LV-GLS) and Holter electrocardiogram (ECG) relevant for prediction of LV systolic dysfunction and outcomes
Original publication
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