Predictive and prognostic value of different cardiac troponin assays: a nationwide register-based cohort study
Authors' conclusion
Siemens Vista cTnI was the strongest predictor of MI and hs-cTnT was the strongest predictor of mortality. An inverted U-shape relationship was observed between cTn concentration and non-cardiovascular mortality.
Study context
- Population
- Patients with acute coronary syndrome (ACS) and ≥ 2 cardiac troponin (cTn) measurements of one of four assays, Danish registries, 2009–1820,550 (23%) had myocardial infarction (MI)
- Participants
- 90,705 patients
- Exposure
- Four cardiac troponin assays compared for predictive and prognostic ability
- Outcome
- MI during admission; all-cause, CV and non-CV mortality (peak cTn normalized to 99th percentile)
- Follow-up
- One-year (mortality)
Methodological detailsDanish registries
- Danish registries
Main finding
As reported in the abstract
MI during admission; 1-year mortality
Siemens Vista cTnI
0.93
AUC for MI (95% CI 0.93-0.93)
hs-cTnTOdds ratio (95% CI)
All-cause mortality, 2-5 times the 99th percentile
21.3(18.4–24.8)
All-cause mortality, >100 times the 99th percentile
12.1(10.3–14.1)
CV mortality, 1-2 times the 99th percentile
11.3(6.4–21.8)
CV mortality, >100 times the 99th percentile
88.8(53.2–163.0)
- Deaths at 1 year
- 9012 (9.9%)
Observational data: associations, not effects.
Original publication
Predictive and prognostic value of different cardiac troponin assays: a nationwide register-based cohort study. Eur Heart J Qual Care Clin Outcomes. Published 20 October 2022. doi:10.
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