Prevention & lipidsCohort study
Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events
- Prospective cohort study
- paired same-day gated and nongated CT
- core laboratory, blinded to acquisition methodology
Authors' conclusion
Nongated CAC predicts cardiovascular events with performance comparable to gated CAC.
Study context
- Population
- MESA exam 5 participants without previous CHD or CVD who underwent same-day gated and nongated chest CT, April 2010 to December 2011of 2601 scanned
- Participants
- 2,472 participants
- Exposure
- Nongated coronary artery calcium (CAC) vs gated CAC for prediction of CHD/CVD events
- Outcome
- Incident CHD/CVD events
Main finding
As reported in the abstract
Incident CHD and CVD by nongated CAC category
Each group vs zero CACHazard ratio (95% CI)
ModerateCHD
2.67(1.14–6.27)
SevereCHD
5.22(2.37–11.5)
ModerateCVD
1.32(1.32–4.04)
SevereCVD
2.89(1.68–4.96)
Observational data: associations, not effects.
Further findings
Correlation of gated and nongated log-standardized CAC
- Pearson r
- 0.961
- P
- P < 0.001
AUC, C-statistic and Brier scores, gated vs nongated CAC
- Statistically similar for gated and nongated CAC
Original publication
Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events. Circulation. Published 27 July 2026. doi:10.1161/circulationaha.125.078431
Summarised from the published abstract; every number is checked against it