Coronary disease & ACSCohort study
Predictive value of early diastolic mitral annular velocity and body mass index as markers of left ventricular relaxation: validation against invasive time constant of relaxation
- cohort
Authors' conclusion
In this cohort, e′ and τ showed only a modest association. LV geometry and BMI were independent contributors to both τ and e′, while age did not significantly affect τ. The determinants of τ and the mean e′ partially overlap and have distinct physiological bases. An increased BMI is associated with impaired LV relaxation.
Study context
- Population
- Patients with suspected coronary artery disease undergoing left heart catheterisationpatients analysed
- Participants
- 419 patients
- Exposure
- Mean e′ against invasively measured left ventricular (LV) relaxation time constant
Main finding
As reported in the abstract
Correlation of mean e′ with τ
r
−0.27
P
P < 0.001
Observational data: associations, not effects.
Further findings
Independent determinants of τ (multivariable analysis)
- LV end-systolic volume index (LVESVI) β
- 0.520
- LVESVI P
- P < 0.001
- heart rate β
- −0.426
- heart rate P
- P < 0.001
- Body mass index (BMI) β
- 0.110
- BMI P
- P = 0.002
- mean e′ β
- −0.088
- mean e′ P
- P = 0.019
- R2
- 0.490
- Age not an independent determinant of τ
Predictors of e′
- age β
- −0.467
- age P
- P < 0.001
- LVESVI β
- −0.368
- LVESVI P
- P < 0.001
- BMI β
- −0.101
- BMI P
- P = 0.015
- R2
- 0.348
- τ did not independently predict e′
Original publication
Predictive value of early diastolic mitral annular velocity and body mass index as markers of left ventricular relaxation: validation against invasive time constant of relaxation. Eur Heart J Cardiovasc Imaging. Published 3 March 2026. doi:10.1093/ehjci/jeag067
Summarised from the published abstract; every number is checked against it