Arrhythmias & electrophysiologyCohort study
Predictive value of notched P wave for life-threatening arrhythmias in patients with Brugada syndrome: Insights from a multicenter prospective study
- multicenter prospective study
- prospective multicenter registry across 61 hospitals in Japan
Authors' conclusion
A notched P wave on a standard 12-lead ECG independently predicts life-threatening arrhythmias in BrS and may improve risk stratification by complementing conventional predictors.
Study context
- Population
- Patients with Brugada syndrome (BrS) (mean age 51 ± 14 years; 95% men)patients with BrS
- Participants
- 510 patients
- Exposure
- Patients with notched P waves vs those without
- Notched P wavesn = 52
Main finding
As reported in the abstract
Cardiac events:
- VF
- Sustained ventricular tachycardia
- Sudden cardiac death
P < 0.001
- Patients experiencing cardiac events, overall
- 58 patients (11%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Event-free survival (Kaplan-Meier) · lower event-free survival in patients with notched P waves | P < 0.001 |
Cardiac events, multivariable Cox regression
- Notched P wave, independent predictor: hazard ratio
- 2.63; 95% confidence interval 1.35-4.78; P = .006
- History of ventricular fibrillation (VF) also an independent predictor
- multivariable
Original publication
Predictive value of notched P wave for life-threatening arrhythmias in patients with Brugada syndrome: Insights from a multicenter prospective study. Heart Rhythm. Published 10 March 2026. doi:10.1016/j.hrthm.2026.03.004
Summarised from the published abstract; every number is checked against it