Predictive Value of Protein-Bound Uremic Toxins for Heart Failure in Patients with Chronic Kidney Disease
Authors' conclusion
Elevated free concentrations of IxS, pCG, and pCS were independently associated with an increased risk of HF events in non-dialysed CKD patients.
Study context
- Population
- Adults with chronic kidney disease (CKD) stages G1-G5 not on dialysis, Ghent University Hospital, Belgium210 with echocardiographic data
- Participants
- 523 adults
- Exposure
- Plasma PBUT concentrations and heart failure (HF)
- Outcome
- Composite of:
- Hospitalization
- Mortality due to HF
- Follow-up
- Median 5.5 years
Methodological detailssingle-centre, Patients included January 2011 to January 2014
- Single-centre
- Patients included January 2011 to January 2014
Main finding
As reported in the abstract
HF hospitalization or HF mortality
Hazard ratio (95% CI)P value
Free IxS
1.71(1.11–2.63)
P = 0.015Free pCS
1.82(1.11–3.01)
P = 0.019Free pCG
1.67(1.08–2.58)
P = 0.020- Patients reaching composite endpoint
- 43 (8.4%)
Observational data: associations, not effects.
Further findings
PBUT levels by left ventricular ejection fraction (LVEF)
- P-cresyl glucuronide (pCG) and p-cresyl sulfate (pCS) significantly higher with reduced (<50%) vs normal LVEF
- P < 0.05
Original publication
Predictive Value of Protein-Bound Uremic Toxins for Heart Failure in Patients with Chronic Kidney Disease. ESC Heart Fail. Published 2 December 2023. doi:10.
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