Valvular & structural heart disease
Predictors and prognostic significance of cardiac damage progression in non-severe aortic stenosis
Authors' conclusion
In non-severe AS, CD is common and frequently progresses over time. CD progression appears to be driven by comorbidities and pre-existing myocardial remodelling and is an independent predictor of all-cause mortality.
Study context
- Population
- Patients with mild or moderate aortic stenosis (AS) at baselinepatients included
- Participants
- 1,751 patients
Methodological detailsserial echocardiographic follow-up
- Serial echocardiographic follow-up
Main finding
As reported in the abstract
Prevalence of advanced-stage (stages 3 and 4) CD · median follow-up of 2.1 (Q1-Q3 1.1-3.6) years
Increased from
24 to 30%
Observational data: associations, not effects.
Further findings
| Outcome | aOR (per additional comorbidity) (95% CI) | P value | |
|---|---|---|---|
| Factors associated with progression to advanced-stage CD — comorbidity burden | 1.23 (1.10–1.38) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Factors associated with progression to advanced-stage cardiac damage (CD)
| Comparison | aOR (95% CI) | P value | |
|---|---|---|---|
| Atrial fibrillation | 3.23 (1.15–9.07) | P = 0.024 | |
| Left atrial dilation | 1.55 (1.11–2.16) | P = 0.010 | |
| 0.10.31310Adjusted odds ratio (log scale) |
All-cause mortality with progression of CD
| Comparison | Adjusted hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Progression of CD · independently associated | 1.35 (1.07–170) | P = 0.012 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Factors associated with progression to advanced-stage CD
- Not AS severity
CD at baseline
- CD present
- 1320 (75%)
- Stage 1
- 231 (13%)
- Stage 2
- 672 (38%)
- Stage 3
- 109 (6%)
- Stage 4
- 308 (18%)
Original publication
Predictors and prognostic significance of cardiac damage progression in non-severe aortic stenosis. Eur Heart J Cardiovasc Imaging. Published 27 July 2026. doi:10.
Summarised from the published abstract; every number is checked against it