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Valvular & structural heart diseaseCohort study

Predictors and prognostic significance of cardiac damage progression in non-severe aortic stenosis

Eur Heart J Cardiovasc ImagingPublished

  • single-centre cohort study with longitudinal follow-up
  • serial echocardiographic follow-up
Read the original article ↗

Authors' conclusion

In non-severe AS, CD is common and frequently progresses over time. CD progression appears to be driven by comorbidities and pre-existing myocardial remodelling and is an independent predictor of all-cause mortality.

Study context

Population
Patients with mild or moderate aortic stenosis (AS) at baselinepatients included
Participants
1,751 patients

Main finding

As reported in the abstract

Prevalence of advanced-stage (stages 3 and 4) CD · median follow-up of 2.1 (Q1-Q3 1.1-3.6) years

increased from

24 to 30%

Observational data: associations, not effects.

Further findings

OutcomeaOR (per additional comorbidity) (95% CI)P value
Factors associated with progression to advanced-stage CD — comorbidity burden1.23 (1.10–1.38)P < 0.001

Factors associated with progression to advanced-stage cardiac damage (CD)

ComparisonaOR (95% CI)P value
atrial fibrillation3.23 (1.15–9.07)P = 0.024
left atrial dilation1.55 (1.11–2.16)P = 0.010

All-cause mortality with progression of CD

Comparisonadjusted hazard ratio (95% CI)P value
Progression of CD · independently associated1.35 (1.07–170)P = 0.012

Factors associated with progression to advanced-stage CD

not AS severity

CD at baseline

CD present
1320 (75%)
stage 1
231 (13%)
stage 2
672 (38%)
stage 3
109 (6%)
stage 4
308 (18%)

Original publication

Predictors and prognostic significance of cardiac damage progression in non-severe aortic stenosis. Eur Heart J Cardiovasc Imaging. Published 27 July 2026. doi:10.1093/ehjci/jeag197
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Summarised from the published abstract; every number is checked against it