Cardio-oncology & otherCohort study
Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry
- Prospective registry study
- multicentre
Authors' conclusion
Prognosis after LSIE is determined by multiple factors, including vegetation size.
Study context
- Population
- Patients with left-sided infective endocarditis (left-sided IE (LSIE)), ESC EURObservational European Infective Endocarditis registry, 2016–18women 31.5%
- Participants
- 2,171 patients
- Outcome
- New embolic event (EE) or death
- Follow-up
- 30 days
Main finding
As reported in the abstract
EE or 30-day mortality
- New EE or death in 30 days
- 459 (21.1%)
- Vegetation size >10 mm (cut-off), HR 1.38 (95% CI 1.13-1.69)
- P = .0015
- EE on admission, HR 1.89 (95% CI 1.54-2.33)
- P < .0001
- History of HF, HR 1.53 (95% CI 1.21-1.93)
- P = .0004
- Creatinine >2 mg/dL, HR 1.59 (95% CI 1.25-2.03)
- P = .0002
- Staphylococcus aureus, HR 1.36 (95% CI 1.08-1.70)
- P = .008
- Congestive HF, HR 1.40 (95% CI 1.12-1.75)
- P = .003
- Haemorrhagic stroke, HR 4.57 (95% CI 3.08-6.79)
- P < .0001
- Alcohol abuse, HR 1.45 (95% CI 1.04-2.03)
- P = .03
- Cardiogenic shock, HR 2.07 (95% CI 1.29-3.34)
- P = .003
- No left-sided surgery, HR 1.30 (95% CI 1.05-1.61)
- P = .016
Observational data: associations, not effects.
Original publication
Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry. Eur Heart J. Published 18 August 2023. doi:10.1093/eurheartj/ehad507
Summarised from the published abstract; every number is checked against it