Valvular & structural heart diseaseCohort study
Predictors of Left Atrial Compliance and V-Wave Response in Patients Undergoing Transcatheter Mitral Valve Therapy
- Retrospective cohort study
- single-centre
Authors' conclusion
Low LA strain and prior AF intervention or LAA ligation may predict low invasive LA compliance and limited V-wave reduction after TMVT.
Study context
- Population
- Patients undergoing transcatheter edge-to-edge repair or valve-in-valve TMVR at the Cleveland Clinic, 2019–2023
- Participants
- 255 patients
- Exposure
- Compliant vs noncompliant left atrial (LA) in patients undergoing transcatheter mitral valve therapy (TMVT)
- Compliant LAn = 107reference
- Noncompliant LAn = 148
- Outcome
- Noninvasive predictors of invasive LA compliance and V-wave response
Main finding
As reported in the abstract
Predictors of low invasive LA compliance (multivariable analysis)
Each group vs compliant LAOdds ratio (95% CI)P value
Low LA reservoir strain
0.89(0.83–0.95)
P = 0.001Prior AF intervention or LAA ligation
4.27(1.43–12.72)
P = 0.009Observational data: associations, not effects.
Further findings
Composite of HF hospitalization and mortality · 1 year
- Low LA compliance significantly associated with increased composite outcome
Original publication
Predictors of Left Atrial Compliance and V-Wave Response in Patients Undergoing Transcatheter Mitral Valve Therapy. JACC Cardiovasc Interv. Published 29 January 2026. doi:10.1016/j.jcin.2025.11.038
Summarised from the published abstract; every number is checked against it