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Valvular & structural heart diseaseResearch article

Predictors of long-term structural valve deterioration and failure after transcatheter aortic valve implantation

EuroInterventionPublished

  • Patients with severe aortic valve stenosis enrolled in the Medtronic One Hospital Clinical Service at 10 Italian centres were included in the study
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Authors' conclusion

Echo-Doppler-derived ERMPG measured within 90 days from TAVI is an independent predictor of SVD. SVD is associated with high rates of BVF, and it is an independent predictor of all-cause mortality and cardiovascular mortality.

Study context

Population
Patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI) with a CoreValve/Evolut valve, September 2007 to December 2014patients undergoing TAVI with a CoreValve/Evolut valve who met the enrolment criteria
Participants
1,291 patients
Comparison
Early residual mean postprocedural gradient (ERMPG) as predictor of structural valve deterioration (SVD); SVD compared with no SVD for 10-year mortality
  • SVDn = 46

Main finding

As reported in the abstract

SVD · median follow-up of 59.4 months

patients with SVD

46

cumulative incidence rate

3.6%

Further findings

OutcomeEstimateP value
ERMPG as independent predictor of SVD · multivariable analysisadjusted sHR 1.05 (95% CI 1.01–1.08)P = 0.004
All-cause mortality · 10-yearadjusted hazard ratio 2.12 (95% CI 1.49–3.00)P < 0.001
Cardiac mortality · 10-yearadjusted sHR 5.78 (95% CI 2.63–12.71)P < 0.001

Risk of SVD across tertiles of ERMPG

significant stepwise increase
P = 0.009

Bioprosthetic valve failure (BVF) among patients with SVD

of the 46 patients with SVD, had or developed BVF
25 (54.3%)

Original publication

Predictors of long-term structural valve deterioration and failure after transcatheter aortic valve implantation. EuroIntervention. Published 19 January 2026. doi:10.4244/eij-d-25-00575
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Summarised from the published abstract; every number is checked against it