Arrhythmias & electrophysiologyResearch article
Predictors of stroke volume improvement with atrioventricular (AV)-optimized conduction system pacing in patients with AV dromotropathy
- Not stated
Authors' conclusion
Echocardiographically assessed mechanical AV dyssynchrony, rather than electrocardiographic parameters, is associated with an acute haemodynamic response to pacing. Echocardiographic evaluation may help identify patients with prolonged PR interval who could benefit from AV-optimized CSP.
Study context
- Population
- Patients with symptomatic first-degree AV blockmean age 60.5 ± 21.1 years, 37% female
- Participants
- Nineteen patients
- Comparison
- Electrocardiographic parameters (PR interval, P wave duration/PR interval ratio) and echocardiographic indices (E/A wave confluence, A-Q interval, and DFT/RR ratio) tested for association with change in left ventricular stroke volume (LVSV)
Main finding
As reported in the abstract
Baseline parameters · baseline
mean PR interval
395 ± 61 ms
mean A-Q interval
155 ± 65 ms
mean DFT/RR ratio
0.34 ± 0.1
E/A wave confluence present
15 patients (79%)
Further findings
Change in LVSV with AV-optimized pacing
- LVSV increase
- 7.8 ± 3.9 ml
- relative increase
- 11.8 ± 5.7%
- P
- P < 0.01
Association of echocardiographic parameters with LVSV response
- A-Q interval
- r = 0.63, P = .004
- DFT/RR ratio
- r = −0.59, P = .008
- E/A wave confluence
- r = 0.57, P = .01
Association of electrocardiographic parameters with LVSV change
- Electrocardiographic parameters were not associated with LVSV change
Original publication
Predictors of stroke volume improvement with AV-optimized conduction system pacing in patients with AV dromotropathy. ESC Heart Fail. Published 19 February 2026. doi:10.1093/eschf/xvag060
Summarised from the published abstract; every number is checked against it