Predictors of target lesion failure after percutaneous coronary intervention with a drug-coated balloon for de novo lesions
Authors' conclusion
In de novo coronary artery lesions that received DCB treatment, factors associated with TLF were being on HD, the presence of a severely calcified lesion, and the absence of post-PCI medial dissection.
Study context
- Population
- Patients with de novo coronary artery lesions treated by percutaneous coronary intervention (PCI) with a drug-coated balloon (DCB) without a stent
- Participants
- 328 lesions
- Exposure
- Target lesion failure (TLF) vs no TLF
- TLFn = 31
- Outcome
- TLF (culprit lesion-related cardiac death, MI, target lesion revascularisation) and its associated factors
- Follow-up
- Median 460 days
Methodological detailsOptical coherence tomography (OCT) pre- and post-PCI
- OCT pre- and post-PCI
Main finding
As reported in the abstract
Independent predictors of TLF (Cox multivariable analysis)
TLF
9.5%
31 of 31
Hazard ratio (95% CI)P value
HD vs No TLFhaemodialysis
2.26(1.00–5.11)
P = 0.049Maximum calcium arc (per 90°)
1.34(1.05–1.72)
P = 0.02Absence of post-PCI medial dissection on OCT vs No TLF
8.24(3.15–21.6)
P < 0.001Observational data: associations, not effects.
Further findings
Characteristics, TLF vs no TLF
HD
Median maximum calcium arc TLF 215° · No TLF 104°
OCT medial dissection
Original publication
Predictors of target lesion failure after percutaneous coronary intervention with a drug-coated balloon for de novo lesions. EuroIntervention. Published 1 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it