Heart failure & cardiomyopathiesSecondary analysis
Predictors of the Efficacy of His Bundle Pacing in Patients with a Prolonged PR Interval: A Stratified Analysis of the HOPE-HF Randomized Controlled Trial
- Secondary analysis of the HOPE-HF randomised trial
- pre-specified secondary analysis
- double-blind
- placebo-controlled
- Bayesian ordinal model
Authors' conclusion
In the HOPE-HF trial, the acute haemodynamic response to pacing reliably identified patients who obtained clinical benefit.
Study context
- Population
- Patients with LVEF ≤40%, PR interval ≥200 ms, and baseline QRS ≤140 ms or right bundle branch block
- Participants
- 167 patients
- Comparison
- Atrio-ventricular (AV)-optimized His bundle pacing vs placebo, by baseline predictors
Primary result
As reported in the abstract
Interaction of baseline predictors with blinded benefit of pacing
- Beneficial interaction of baseline acute haemodynamic response with pacing benefit: VO2
- Pr 99.9%
- Beneficial interaction of baseline acute haemodynamic response with pacing benefit: Minnesota Living With Heart Failure (MLWHF)
- Pr 99.8%
- Beneficial interaction of baseline acute haemodynamic response with pacing benefit: MLWHF physical limitation score
- Pr 98.9%
- Beneficial interaction of baseline acute haemodynamic response with pacing benefit: EQ-5D visual analogue scale
- Pr 99.6%
- Beneficial interaction of baseline acute haemodynamic response with pacing benefit: exercise time
- Pr 99.4%
Original publication
Predictors of the Efficacy of His Bundle Pacing in Patients with a Prolonged PR Interval: A Stratified Analysis of the HOPE-HF Randomized Controlled Trial. Eur J Heart Fail. Published 18 July 2024. doi:10.1002/ejhf.3367
Summarised from the published abstract; every number is checked against it