Arrhythmias & electrophysiology
Predictors of pacemaker requirement in patients receiving implantable loop recorders for unexplained syncope: A systematic review and meta-analysis
Authors' conclusion
Approximately one-quarter of ILR recipients for unexplained syncope require eventual PPM insertion. Advancing age, PR prolongation, and distal conduction disease are the strongest predictors for PPM requirement.
Study context
- Population
- ILR recipients with unexplained syncope
- Participants
- 1,007 recipients · 8 studies
- Comparison
- Permanent pacemaker (PPM) recipients vs non-recipients among ILR recipients
- PPMn = 268
- Outcome
- Predictors of PPM insertion (pooled OR of clinical and ECG characteristics)
- Follow-up
- Study
Methodological detailsrandom effects model, Search of MEDLINE, Embase, Scopus, Cochrane in June 2023
- Random effects model
- Search of MEDLINE, Embase, Scopus, Cochrane in June 2023
Pooled result
As reported in the abstract
Predictors of PPM requirement
PPM
26.6%
268
Pooled odds ratio (95% CI)
PR prolongation on baseline ECGPPM requirement
2.91(1.63–5.20)
Distal conduction system disease (any bundle branch or fascicular block)PPM insertion
2.88(1.53–5.41)
Further pooled results
Age
P < 0.001
Indication for PPM insertion
- Sinus node dysfunction
- 62%
- AV block
- 26%
Original publication
Predictors of pacemaker requirement in patients receiving implantable loop recorders for unexplained syncope: A systematic review and meta-analysis. Heart Rhythm. Published 18 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it