Heart failure & cardiomyopathiesCohort study
Pregnancy-Associated Cardiomyopathy and Long-Term Cardiac Phenotype in Women With Truncating Titin Variants
- ambispective cohort study
- consecutive TTNtv genotype-positive women, regardless of phenotype
Authors' conclusion
In this TTNtv-positive cohort, PAC incidence appeared higher than reported PPCM rates in the general European population. However, pregnancy was well tolerated and was not associated with adverse long-term cardiac remodeling.
Study context
- Population
- TTNtv genotype-positive women with ≥1 cardiological evaluationTTNtv-positive women (17% probands), 78 with prior pregnancies
- Participants
- 107 women
- Exposure
- parous vs nulliparous
Main finding
As reported in the abstract
Live births
206 pregnancies among 78 women with prior pregnancies resulted in live births
167 (81%)
Observational data: associations, not effects.
Further findings
Pregnancy-associated cardiomyopathy (PAC)
- PAC in live births
- 3 of 167
- PAC in women
- 3 of 76
- cumulative incidence per live birth
- 1.8%
- cumulative incidence per woman
- 3.9%
- All affected women recovered completely with medical therapy
Maternal and fetal adverse events in remaining pregnancies
- Remaining pregnancies were largely uncomplicated, without increased maternal or fetal adverse events
Arrhythmic burden, cardiac function, ventricular dimensions · median of 18 years (IQR: 9-31) after pregnancy
- no differences were observed between parous and nulliparous women
Original publication
Pregnancy-Associated Cardiomyopathy and Long-Term Cardiac Phenotype in Women With Truncating Titin Variants. JACC Adv. Published 3 June 2026. doi:10.1016/j.jacadv.2026.102857
Summarised from the published abstract; every number is checked against it