Coronary disease & ACSCohort study
Pregnancy-Associated Spontaneous Coronary Artery Dissection
- Cohort study
- multicentre registry
Authors' conclusion
In this contemporary cohort, women with P-SCAD continue to represent a higher-risk phenotype with predominantly conservative management; however, they had less LVEF recovery.
Study context
- Population
- Women with spontaneous coronary artery dissection (SCAD) and ≥1 prior pregnancy, iSCAD Registry, 2019–2024
- Participants
- 907 women
- Exposure
- P-SCAD vs NP-SCAD
- P-SCADn = 98
- Outcome
- Survey-based clinical and reproductive history variables corroborated with investigator-extracted clinical and imaging data, including SCAD event characterization
Main finding
As reported in the abstract
- Fibromuscular dysplasia: P-SCAD 27 of 86 [31%] vs NP-SCAD 309 of 681 [45%]
- P = .01
- Preeclampsia: P-SCAD 24 of 98 [25%] vs NP-SCAD 101 of 809 [13%]
- P = .001
- STEMI: P-SCAD 16 of 86 [18.6%] vs NP-SCAD 40 of 733 [5.5%]
- P < .001
- Multivessel segment involvement: P-SCAD 22 of 70 [31%] vs NP-SCAD 101 of 588 [17%]
- P = .004
- Left ventricular ejection fraction (LVEF) <40%: P-SCAD 4 of 15 [27%] vs NP-SCAD 6 of 105 [7%]
- P = .006
Observational data: associations, not effects.
Further findings
LVEF recovery · 1 year
- Less LVEF recovery with P-SCAD
Primarily medical management (both groups)
- Primarily medically managed
- 661 of 887 [75%]
Original publication
Pregnancy-Associated Spontaneous Coronary Artery Dissection. JAMA Cardiol. Published 1 June 2026. doi:10.1001/jamacardio.2026.1009
Summarised from the published abstract; every number is checked against it