Cardio-oncology & otherCohort study
Pregnancy in Women With Impaired Left Ventricular Function
- international, prospective, observational cohort
- registry (ROPAC)
Authors' conclusion
Women with impaired LVF are at increased risk of complications, particularly heart failure, tachyarrhythmias, and premature delivery with low birth weight.
Study context
- Population
- Pregnant women with impaired left ventricular function (left ventricular ejection fraction <40%)patients with impaired left ventricular function (LVF)
- Participants
- 251 women
- Outcome
- MACE:
- Maternal death
- Supraventricular or ventricular arrhythmias
- Heart failure
- Aortic dissection
- Endocarditis
- Ischemic coronary event
- Other thromboembolic events
- Follow-up
- During pregnancy or up to 6 months postpartum
Main finding
As reported in the abstract
Patients with at least one major adverse cardiac events (MACE)
81 of 251 (32%, 27%-38%)
Observational data: associations, not effects.
Further findings
Maternal mortality
- Maternal mortality
- 6/251 (2.4%, 1%-5%)
Heart failure
- Heart failure
- 67/251 (27%, 21%-33%)
Ventricular tachyarrhythmias
- Ventricular tachyarrhythmias
- 11/251 (4%, 2%-8%)
Obstetric complications
- Preterm birth
- 67/251 (27%, 22%-33%)
- Low birthweight
- 65/251 (26%, 21%-32%)
Cardiovascular complications in patients with cardiomyopathy · during pregnancy
- Mortality
- 4.3%
- Risk of MACE
- nearly 40%
Variables associated with poor cardiac outcomes
- Prepregnancy signs of heart failure, OR
- 2.67; 1.3-5.6
- Atrial fibrillation, OR
- 6.32; 3.0-13.3
- NYHA functional class >II, OR
- 6.06; 2.2-16.6
- logistic regression
Follow-up duration
- Median follow-up duration
- 7 (6-11) months
Original publication
Pregnancy in Women With Impaired Left Ventricular Function. JACC Adv. Published 25 February 2026. doi:10.1016/j.jacadv.2026.102605
Summarised from the published abstract; every number is checked against it