Heart failure & cardiomyopathiesCohort study
Pregnancy-Induced Hypertensive Disorder and Risks of Future Ischemic and Nonischemic Heart Failure
- Population-based matched cohort study
- Swedish Medical Birth Register
Authors' conclusion
Pregnancy-induced hypertensive disorder is associated with an increased short-term and long-term risk of incident ischemic and nonischemic heart failure. Disease characteristics indicating more severe forms of pregnancy-induced hypertensive disorder amplify the heart failure risks.
Study context
- Population
- Primiparous women without a history of CVD in the Swedish Medical Birth Register, 1988–2019matched cohort
- Participants
- 79,334 vs 396,531
- Exposure
- Pregnancy-induced hypertensive disorder vs normotensive pregnancy
- Pregnancy-induced hypertensive disordern = 79,334
- Normotensive pregnanciesn = 396,531reference
- Outcome
- Incident HF, classified as ischemic or nonischemic
- Follow-up
- Median 13 years
Main finding
As reported in the abstract
Pregnancy-induced hypertensive disorder vs Normotensive pregnanciesAdjusted hazard ratio (95% CI)
HF overall
1.70(1.51–1.91)
ischemic HF
2.28(1.74–2.98)
nonischemic HF
1.60(1.40–1.83)
Observational data: associations, not effects.
Further findings
HF rates by disease severity
- Disease characteristics indicating severe hypertensive disorder were associated with higher HF rates
Timing of HF risk
- Rates highest within the first years after the hypertensive pregnancy but remained significantly increased thereafter
Original publication
Pregnancy-Induced Hypertensive Disorder and Risks of Future Ischemic and Nonischemic Heart Failure. JACC Heart Fail. Published 10 May 2023. doi:10.1016/j.jchf.2023.03.021
Summarised from the published abstract; every number is checked against it