Valvular & structural heart diseaseCohort study
Pregnancy with a prosthetic heart valve, thrombosis, and bleeding: the ESC EORP Registry of Pregnancy and Cardiac disease III
- Prospective registry study
- global registry
Authors' conclusion
More favourable outcomes were found in women with a biological valve compared with a mechanical valve.
Study context
- Population
- Pregnancies in women with a prosthetic heart valve, January 2018 to April 2023
- Participants
- 613 pregnancies
- Exposure
- Mechanical vs biological prosthetic heart valve in pregnancy
- Mechanical valven = 411
- Biological valven = 202reference
- Outcome
- Uncomplicated pregnancy with a live birth
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Thromboembolic event by anti-Xa monitoring
P = 0.060
Foetal death
- Foetal death, all pregnancies
- 20%
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| Valve thrombosis · association with valve thrombosis | 3.3 (1.9–8.0) | |
| 0.10.31310Odds ratio (log scale) |
- Valve thrombosis — Valve thrombosis, women
- 24 (6%)
Valve thrombosis
- Thromboembolic and haemorrhagic complications most frequent with low-molecular weight heparin (LMWH)-based regimens
Original publication
Pregnancy with a prosthetic heart valve, thrombosis, and bleeding: the ESC EORP Registry of Pregnancy and Cardiac disease III. Eur Heart J. Published 16 April 2025. doi:10.1093/eurheartj/ehaf265
Summarised from the published abstract; every number is checked against it