Prehospital antiplatelet therapy in patients with out-of-hospital cardiac arrest suspected of acute coronary syndrome
Authors' conclusion
Prehospital antiplatelet therapy was safe, but showed no apparent improvement in survival or cardiovascular outcomes in patients with OHCA suspected of ACS.
Study context
- Population
- Patients with out-of-hospital cardiac arrest (OHCA) suspected of acute coronary syndrome (ACS) referred for coronary angiography within 24 h, 2012 to 2024admitted to the cath lab within 24 h after OHCA
- Participants
- 411 patients
- Comparison
- Patients who received a prehospital treatment vs those who did not
- Prehospital antiplatelet therapyn = 217
- Outcome
- 30-day all-cause death
- Follow-up
- 30 days
Methodological detailsinverse probability weighting
- Inverse probability weighting
Main finding
As reported in the abstract
P = 0.280
Further findings
In-hospital major adverse cardiovascular events (MACE)
- Not significantly different between the two strategies
Subgroups: ST-segment elevation or successfully resuscitated patients
- Results appear to be consistent
Safety
In-hospital major bleeding (BARC ≥ 3)
- Not significantly different between the two strategies
Original publication
Prehospital antiplatelet therapy in patients with out-of-hospital cardiac arrest suspected of acute coronary syndrome. Resuscitation. Published 28 March 2025. doi:10.
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