Prehospital crushed versus integral prasugrel loading dose in STEMI patients with a large myocardial area
Authors' conclusion
Administration of crushed prasugrel may improve postprocedural TIMI 3 flow in STEMI patients with signs of a large myocardial area at risk on the ambulance ECG.
Study context
- Population
- STEMI patients from the CompareCrush trial with available ambulance electrocardiography (ECG), by prehospital large myocardial area at risk331 with large myocardial area
- Participants
- 532 patients
- Comparison
- Crushed vs integral prehospital prasugrel loading dose
- Primary endpoint
- Postprocedural Thrombolysis in Myocardial Infarction (TIMI) 3 flow in the infarct-related artery
Primary result
As reported in the abstract
Postprocedural TIMI 3 flow, by prehospital large myocardial area at risk (subgroups)
Crushed prasugrel vs Integral prasugrelOdds ratio (95% CI)
Large myocardial area at risk: 92% vs 79%
3.00(1.50–6.00)
No large myocardial area at risk: 91% vs 95%
0.47(0.14–1.57)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prehospital crushed versus integral prasugrel loading dose in STEMI patients with a large myocardial area. EuroIntervention. Published 1 April 2024. doi:10.
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