Heart failure & cardiomyopathiesMeta-analysis
Premature ventricular contraction–induced ventricular dysfunction in children without structural heart disease: a systematic review and meta-analysis
- Systematic review and meta-analysis
Search of original reports published 1 January 2000 to 31 August 2024; mean age 11.4 years
Authors' conclusion
Premature ventricular contraction-induced CMP is rare in children, and PVC burden is the key determinant of risk. The threshold burden associated with LV dysfunction is higher in paediatric patients than in adults. Most patients with PVC-induced CMP experience normalization of LV function during follow-up.
Study context
- Population
- Paediatric patients with premature ventricular contractions (PVCs) and structurally normal hearts (no cardiomyopathies, congenital heart diseases or channelopathies)
- Participants
- 1.701 patients · 17 studies
- Comparison
- Left ventricular (LV) dysfunction vs No LV dysfunction
- Outcome
- Prevalence of PVC-induced cardiomyopathy and its risk factors
Pooled result
As reported in the abstract
PVC-induced LV systolic dysfunction; PVC burden as risk factor
Mean PVC burden
- Mean PVC burden across included studies
- 16% (12.2-19.7)
Further pooled results
Other predictors
- Shorter coupling intervals and longer QRS duration were predictors in a few studies
Recovery of LV dysfunction
- LV dysfunction recovered in all but one patient after spontaneous or pharmacological PVC reduction
- Class IC drugs showed greater efficacy than other drugs
Safety
MACE
- No major adverse CV events occurred
Original publication
Premature ventricular contraction–induced ventricular dysfunction in children without structural heart disease: a systematic review and meta-analysis. Europace. Published 11 August 2025. doi:10.1093/europace/euaf167
Summarised from the published abstract; every number is checked against it