Arrhythmias & electrophysiologyCohort study
Premature ventricular contractions burden and long-term ventricular remodelling in patients without structural heart disease
- retrospective study
Authors' conclusion
A PVC burden >1% was associated with long-term ventricular structural or functional remodelling. Given the dynamic nature of PVC burden, even patients with 1-10% burden may warrant follow-up monitoring, as a single 24-hour Holter may underestimate future risk.
Study context
- Population
- Patients with premature ventricular complexes (PVCs) without structural heart disease who underwent Holter monitoring and echocardiography between February 2007 and July 2017 at the Asan Medical Center, Koreapatients with PVCs without structural heart disease (mean age 58.8±13.1 years, 47.1% female)
- Participants
- 5,040 patients
- Exposure
- PVC burden 1%-10% or ≥10% compared with <1%
- Outcome
- Composite of:
- Newly developed cardiac structural or functional remodelling
- Including LV systolic dysfunction (<40%)
- Severe LV enlargement and moderate-to-severe mitral and tricuspid regurgitations
- Follow-up
- 8 years
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
LV dysfunction
LV enlargement
- Left ventricular (LV) dysfunction: p=0.009
- LV enlargement: p=0.007
Baseline characteristics by PVC burden
- Higher PVC burden was associated with younger age, fewer comorbidities and lower baseline LV ejection fraction
Original publication
Premature ventricular contractions burden and long-term ventricular remodelling in patients without structural heart disease. Heart. Published 28 May 2026. doi:10.1136/heartjnl-2025-327560
Summarised from the published abstract; every number is checked against it