Prevention & lipidsCohort study
Prenatal and postnatal nutritional mismatch, reflected by birth weight and adult body mass index, and cardiometabolic disease risk
- Prospective cohort study with Mendelian randomisation analysis
- 2 × 2 factorial Mendelian randomization
Authors' conclusion
Combined exposure to LBW and HBMI was most strongly associated with an elevated risk of CMD, underscoring the critical role of the mismatch between early-life and adult nutritional status in shaping long-term cardiometabolic health.
Study context
- Population
- UK Biobank participants of White European ancestry
- Participants
- 254,224 participants
- Exposure
- Birth weight and adult body mass index (BMI) categories
Main finding
As reported in the abstract
ASCVD
Each group vs HBW-LBMIHazard ratio (95% CI)
LBW-LBMI
1.19(1.12–1.26)
HBW-HBMI
1.33(1.28–1.38)
LBW-HBMI
1.62(1.50–1.75)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Hypertension, diabetes, hyperlipidaemia (LBW-HBMI) — LBW-HBMI vs HBW-LBMI · hypertension | 2.42 (2.26–2.59) | |
| Hypertension, diabetes, hyperlipidaemia (LBW-HBMI) — LBW-HBMI vs HBW-LBMI · diabetes | 5.16 (4.73–5.63) | |
| Hypertension, diabetes, hyperlipidaemia (LBW-HBMI) — LBW-HBMI vs HBW-LBMI · hyperlipidaemia | 1.95 (1.81–2.10) | |
| 0.20.5125Hazard ratio (log scale) |
Hypertension, diabetes, hyperlipidaemia (LBW-HBMI)
- Additive interactions between LBW and HBMI for metabolic diseases
Causality (Mendelian randomization (MR) analysis)
- Causality of associations confirmed by MR analysis
Original publication
Prenatal and postnatal nutritional mismatch, reflected by birth weight and adult body mass index, and cardiometabolic disease risk. Eur J Prev Cardiol. Published 6 February 2025. doi:10.1093/eurjpc/zwaf059
Summarised from the published abstract; every number is checked against it