Coronary disease & ACSCohort study
Prevalence and prognostic impact of high ischaemic risk criteria in chronic coronary syndrome patients undergoing percutaneous coronary intervention (PCI)
- retrospective
- real-world cohort
- single-centre (Mount Sinai Hospital)
- multivariate Cox regression
Authors' conclusion
In a real-world CCS cohort, guideline-defined HIR status was associated with increased MACCE. However, as almost three-quarters of patients met at least one HIR criterion, risk stratification accuracy at the time of PCI may have been limited.
Study context
- Population
- Chronic coronary syndrome patients treated with drug-eluting stents at Mount Sinai Hospital between 2012 and 2022Chronic coronary syndrome (CCS) patients, 10,952 (71.4%) met at least one high ischaemic risk (HIR) criterion
- Participants
- 15,336 patients
- Exposure
- Guideline-defined HIR status and number of HIR criteria vs major adverse cardiac and cerebrovascular events (MACCE)
- HIRn = 10,952
- Outcome
- MACCE:
- Death
- MI
- Stroke
Main finding
As reported in the abstract
Increasing numbers of HIR criteria associated with higher MACCE
p for trend<0.001
Observational data: associations, not effects.
Further findings
Death and myocardial infarction (MI) by number of HIR criteria
- Death
- P for trend < 0.001
- MI
- P for trend < 0.001
Prevalence of HIR
- Met at least one HIR criterion
- 10,952 (71.4%)
Original publication
Prevalence and prognostic impact of high ischaemic risk criteria in chronic coronary syndrome patients undergoing PCI. EuroIntervention. Published 6 April 2026. doi:10.4244/eij-d-25-01174
Summarised from the published abstract; every number is checked against it